NICOWebinar: "From advanced cell culture studies to a stem cell therapy for Parkinson´s disease" 19/11/21 at 2.00 pm
Published: Wednesday, November 17, 2021 by Giovanna Gambarotta
Friday 25/11/21 at 2.00 pm - Lecture
Alessandro Fiorenzano, PhD
Lund University (SWE)
From advanced cell culture studies to a stem cell therapy for Parkinson´s disease
Three-dimensional (3D) brain organoids have emerged as a valuable model system for studies of human brain development and pathology. We established a midbrain organoid culture system to study dopamine neuron differentiation trajectory at single cell resolution. Additionally, we are combining single-cell RNA sequencing with histological analyses to characterise intracerebral grafts from human pluripotent stem cells and fetal tissue after functional maturation in a pre-clinical rat PD model. This study uncovers previously unknown cellular diversity in a clinically relevant cell replacement PD model.
Host: Roberta Schellino
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