NICOWebinar: "Dissecting neuronal-glial cross-talk" - Friday 5/11/21 at 2.00 pm
Friday 5/11/21 at 2.00 pm - Lecture
Wannan Tang
Department of Clinal and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Norway
Dissecting neuronal-glial cross-talk
Accumulating evidence in the recent decade indicates that the long neglected glial cells are tightly engaged in brain network function. However, up to now, it is not established how glial activities are modulating neuronal circuit function. In modern Neurophysiology, the use of genetically encoded fluorescent sensors and opto-/chemogenetic manipulation of neurons allowed to identify the generation of neuronal circuits in the forebrain that are critically involved in the learning of specific behaviors. There is emerging evidence that the glial cells are actively involved and necessary for the establishment of these circuits. In our study, we aim to analyze glial physiology and neuronal-glial communication in the mouse brain using and developing novel genetically encoded fluorescent sensors, chemogenetic and optogenetic approaches in the mouse brain both ex vivo and in vivo. Our studies utilize virally delivered genetically encoded fluorescent sensors of various molecules for glial physiology studies in the acute brain slices, as well as for head-fixed awake mice under behavioral tasks in combination with two-photon microscopy.
Host: Ilaria Bertocchi
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