Cellular and Molecular Biology

NeuroWebinar

Friday 12/3/21 at 2:00 pm - Lecture

Lorena Perrone
Université Grenoble Alpes, Grenoble, France

Thioredoxin Interacting Protein and Warburg effect: metabolism driving neurovascular inflammation. Molecular pathways and innovative nanotechnology-based diagnostic.

The major mechanism of cell metabolism reprogramming is defined as the Warburg effect, which consists in a preferential utilization of glucose via glycolysis even in the presence of oxygen. The glucose transporter Glut1 plays a key function in the Warburg effect. Thioredoxin Interacting Protein (TXNIP) is the endogenous inhibitor of the ROS scavenger Thioredoxin (Trx) and also the major regulator of the Glut1 endocytosis. Thus, TXNIP modulates glucose uptake and metabolism.

I will summarize my results showing the different functions of TXNIP in the nervous system. Transient expression of TXNIP is essential for the repair. On the contrary, chronic expression of TXNIP promotes a cascade of cell-specific pathways that ultimately promote neurodegeneration. Notably, silencing of TXNIP prevents in vivo the progression of Diabetic Retinopathy and Alheimer's Disease.

Host: Ferdinando Di Cunto

webex link  | Meeting ID: 815 1954 6054 | Passcode: 489006

Barbara Magnani