Cellular and Molecular Biology

GENERAL AND MOLECULAR PHARMACOLOGY

GENERAL AND MOLECULAR PHARMACOLOGY

Academic year 2023/2024

Sommario del corso

• Course objectives
• Results of learning outcomes
• Program
• Course delivery
• Learning assessment methods
• Suggested readings and bibliography
• Teaching tools
• Course card

Course objectives

This teaching contributes to the learning objectives included in the Fundamental Area of the Master in Cellular and Molecular Biology - Biologia Cellulare e Molecolare, providing:

• core and advanced knowledge of the fundamental principles of drug action at the molecular level, through which students will be able to connect the action of selected groups of clinically important drugs with body's responses
• drug knowledge not only as a therapeutic tool but also as a research tool, so students will be able to understand preclinical and clinical research strategies for drug development
• scientific thinking through the development of students' critical analysis skills, so students will be able to understand experimental approaches and data of scientific literature improving their knowledge as well as their research skills 

Results of learning outcomes

• Understanding of drug principles and molecular targets of selected groups of clinically important drugs
• Practical experience of pharmacokinetic/ pharmacodynamic studies
• Research skills to characterize drug action
• Pre-clinical and clinical strategies for drug discovery and development

Program

Part I - General Pharmacology 

• Introduction to Molecular Pharmacology
• Drug Discovery and Development
• Drug Disposition
• Pharmacokinetics
• Individualization of Drug Therapy
• Pharmacodynamics

Part II - Molecular Pharmacology 

• Drugs Acting on G-Protein-Coupled Receptors
• Drugs Acting on Ion Channels
• Drugs Acting on Membrane Transporters
• Drugs Acting on Protein Pumps
• Drugs Acting on Enzymes
• Drugs Acting on Nucleic Acids
• Drugs Acting on Enzyme-Linked Receptors
• Drugs Acting on Nuclear Receptors
• Drugs Acting on Immune System
• Biotechnological drugs
• Lectures delivered by Guest Professors on specific topics

Course delivery

The course will consist in 48 teaching hours delivered in presence, subject to updates on the measures adopted by UniTo which can be found on the University portal under "Provisions for those who study and work at UniTo" (see https://en.unito.it/studying-unito). Moreover, supporting material consisting of scientific articles and videos will be also delivered for helping the Student comprehension of each topic. Finally, a General and Molecular Pharmacology Forum will be open to post questions and/or doubts about the topics covered during the General and Molecular Pharmacology Course to increase the interaction between Students and Professor and among Students.

Learning assessment methods

The General and Molecular Pharmacology examination will consist of a written test and an oral examination.

The written test will consist of 60 multiple-choice questions based on the entire General and Molecular Pharmacology course (four answers, of which only one is correct and with a penalty for each wrong answer. No penalty for missing answers) in a 40-minute Moodle session, setting the navigation method as sequential. Only students scoring 18 out of 30 points in the written test will be admitted to the oral examination. The oral examination will generally be held on the same day as the written test. 

The final score will be an average bewteen the scores from the written test and oral examination.

Exams will take place exclusively in presence, subject to updates on the measures adopted by UniTo which can be found on the University portal under "Provisions for those who study and work at UniTo" (see https://en.unito.it/studying-unito). 

Academic conduct: The penalty for course-related dishonesty (ei. cheating on exams, plagiarism, etc) will be a failure for the entire course

Teaching Materials:

• "Molecular Pharmacolgy Course" on the Moodle platform

Reference Books:

• Goodman & Gilman's "The pharmacological basis of therapeutics" Mc Graw Hill Ed.
• Katzung "Basic & Clinical Pharmacology" Mc Graw Hill Ed.
• Rang & Dale "Pharmacology" Elsevier Ed.
• Clementi & Fumagalli "General and Molecular Pharmacology" Wiley Ed.

Websites of Interest:

• http://www.nature.com/pharma
• http://www.ncbi.nlm.nih.gov
• http://www.bps.ac.uk
• http://www.drugbank.ca

• Teaching material
• Exams and finals
• Class schedule
• Go to Moodle
• Register for the course
• Enrolled students
• Invia email agli studenti registrati
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