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GENERAL AND MOLECULAR PATHOLOGY (not activated)
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GENERAL AND MOLECULAR PATHOLOGY
- Course ID
- SVB0045
- Teachers
- Riccardo Autelli
Fabio Penna - Degree course
- Cellular and Molecular Biology
- Year
- 1st year
- Teaching period
- To be defined
- Type
- Distinctive
- Credits/Recognition
- 6
- Course disciplinary sector (SSD)
- MED/04 - experimental medicine and pathophysiology
- Delivery
- Formal authority
- Language
- English
- Attendance
- Lessons optional and laboratories mandatory
- Type of examination
- Written
- Prerequisites
- Structure and function of biological macromolecules.
Cellular and molecular biology.
Cytology and histology.
Structure and function of organs.
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Sommario del corso
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Course objectives
Aim of the course is to provide students with instruments to understand
the molecular bases of some human diseases.
Students will be able to establish connections between molecular
alterations and the pathogenesis of pathological processes at higher
integration levels (subcellular compartments, cells, tissues and organs,
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Results of learning outcomes
KNOWLEDGE AND UNDERSTANDING:
Understanding of the main pathogenetic mechanisms involved in the pathogenesis of the most frequent human diseases as well as in some rare diseases.
APPLYING KNOWLEDGE AND UNDERSTANDING:
Identification of the most important histological aspects of inflammatory lesions, tissue necrosis, fibroproliferative diseases.
JUDGEMENT:
Analysis and interpretation of data from the literature
COMMUNICATION SKILLS:
Oral and written communication with an adequate technical language in both italian and english.
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Program
Disease and syndrome. Extrinsic and intrinsic causes of disease and their interactions. Unifactorial e multifactorial diseases.
Cellular responses to stress and toxic insults: adaptation, injury and death. Oxidative stress. Ischemia-reperfusion damage. Physiological and pathological ageing, tissue and cellular senescence.
Inflammation: acute inflammation, cells and mediators. Evolution. Chronic inflammation. Role of inflammation in cancer, basic notions of oncology and tumor classification.
Immunopathology: hypersensitivity, autoimmune diseases, immune deficiency.
DNA repair defects and their consequences. Germ cells, stem cells, neoplastic cells. Macromolecular turnover, cell death.
Fibroproliferative diseases: atherosclerosis and cirrhosis.
Endoplasmic reticulum stress. Protein misfolding. Intracellular protein accumulation as pathogenetic mechanism: amyloidosis and neurodegenerative diseases.
Erithrocyte physiopathology: molecular bases of haemoglobin and erithrocyte production and degradation. Mechanisms of anemia.
Radiation biology. Ionizing radiations: direct and indirect effect, cell and tissue damage; radioprotection. Photodynamic diseases.Pathophysiological bases of heart dynamics and circulation diseases. Ischemic heart disease; heart failure. Hypertension. Shock. Thrombosis .
Alteration of glucose homeostasis: diabetes.
Pathology on the web and under the microscope.
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Course delivery
The course is articulated in 46 hours of formal in‐class lecture time and one practical laboratory of histological analysis (2 hours x student).
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Learning assessment methods
Written examination (both short and open answers) on the e-learning platform (moodle).
Suggested readings and bibliography
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- Kumar, Abbas, Aster Robbins & Cotran Pathologic Basis of Disease, 9th edition, Elsevier
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Class schedule
Notes: See the timetable at the Class Schedule Page
- Enroll
- Closed
- Enrollment opening date
- 01/03/2020 at 00:00
- Enrollment closing date
- 31/12/2022 at 23:55
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