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METABOLIC BIOCHEMISTRY
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METABOLIC BIOCHEMISTRY
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Academic year 2023/2024
- Course ID
- SVB0042
- Teachers
- Giovanna Di Nardo
Sheila Sadeghi - Degree course
- Cellular and Molecular Biology
- Year
- 1st year
- Teaching period
- Semester 2
- Type
- Distinctive
- Credits/Recognition
- 6
- Course disciplinary sector (SSD)
- BIO/10 - biochemistry
- Delivery
- Blended
- Language
- Italian
- Attendance
- Lessons optional and laboratories mandatory
- Type of examination
- Written and interview (optional)
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Sommario del corso
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Course objectives
This teaching contributes to the learning objectives included into the Biomolecular area of the Master in Cellular and Molecular Biology - Biologia Cellulare e Molecolare, providing knowledge and applicative abilities on organ-specific and advanced biochemistry by studying the biosynthesis and degradation of specific molecules and cofactors with high impact on metabolic balance, medicine and pharmacology. Furthermore, it aims to elucidate the molecular mechanisms underlining metabolic and hormonal regulation. In the last part, specific metabolic pathways from different organisms will be studied to understand how they are exploited for biotechnological applications.
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Results of learning outcomes
KNOWLEDGE AND UNDERSTANDING.
The students will be able to:
- master advanced biochemical concepts;
- understand the concept of metabolic regulation:
- understand how hormones regulate metabolism;
- understand how xenobiotics are metabolised by organism;
- learn how some metabolic pathways can be exploited for biotechnological applications.
JUDGEMENT AUTONOMY
At the end of the teaching the students will be able to:
- understand a regulation pathway in the picture of the overall metabolism;
- exploit metabolic versatility for different purposes.
COMMUNICATION SKILLStudents will develop the ability to:
- understand conference talks from native speakers about topics described during the lectures.
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Program
Part 1. Advanced metabolic biochemistry.
1- Tissue - specific metabolic regulation.
2- Iron metabolism.
3- Amino acid metabolism: biosynthesis of amino acids.
4- Metabolism molecule derived from amino acids : porphyrins and heme.
5- Protein metabolism; sorting protein destiny, chaperones and folding, protein degradation, diseases linked to proteostasis.
6- Metabolism of xenobiotics: Phase I and Phase II
Part 2. Metabolic and hormonal regulation
1- Hormones: classification, structure and function. Hormone receptors, signal transduction and metabolic effects.
2- The hormonal regulation
3- Steroid and steroid hormones : biosynthesis and regulation . Role and regulation in the endocrine and neuroendocrine .
Part 3. Applied biochemistry
1- Microbial metabolism and fermentation: potential applications
2- Production of biofuels
3- Detoxification of pollutants
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Course delivery
Lectures: 48 hours, that include 2 hours of an extra-activity that is a test on the study and comprehension of two scientific reviews on a specific topic of the course.
All lectures will be delivered in presence, subject to updates on the measures adopted by UniTo which can be found on the University portal under "Provisions for those who study and work at UniTo" (see https://en.unito.it/studying-unito). - Oggetto:
Learning assessment methods
The final exam consists of a written work with two open questions with limited time (12-15 minutes for each question) and space performed on Moodle platform. A third question where formulas are requested is written with 20 minutes of time.
For each question, the maximal grade will be 33. If the average will be more than 30, the exam will be marked 30 cum laude.
In any case, students should gain a sufficient grade (18 out of 30 or more) on all the three questions in order to pass the exam.
Exams will take place in presence, subject to updates on the measures adopted by UniTo which can be found on the University portal under "Provisions for those who study and work at UniTo" (see https://en.unito.it/studying-unito) Academic conduct: The penalty for course-related dishonesty (ei. cheating on exams, plagiarism, etc) will be a failure for the entire course.- Oggetto:
Support activities
Support activities are organized on the Moodle e-learning platform (http://biologia.i-learn.unito.it/ ).
In particular, some recent reviews about topics related to lectures will be provided.
A quiz for the assessment of the reading and comprehension is performed as an extra activity.
A forum on Moodle will be also available for any request from the students.
Suggested readings and bibliography
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David L. Nelson, Albert L. Lehninger, Lehninger principles of biochemistry.
Robert K. Murray, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, Victor W. Rodwell, P. Anthony Weil. Harper's Illustrated Biochemistry
Slides and notes of the lectures.
Recent reviews and reserach papers indicated during the lectures and available on the Moodle e-learning platform (http://biologia.i-learn.unito.it/ ).
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Class schedule
Notes: See the timetable at the Class Schedule Page
- Enroll
- Closed
- Enrollment opening date
- 01/03/2020 at 00:00
- Enrollment closing date
- 31/12/2022 at 23:55
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