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DEVELOPMENTAL NEUROBIOLOGY (ON-LINE)

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DEVELOPMENTAL NEUROBIOLOGY (ON-LINE)

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Academic year 2023/2024

Course ID
SVB0195
Teacher
Silvia De Marchis (Coordinator)
Degree course
Cellular and Molecular Biology
Year
1st year
Teaching period
Semester 2
Type
Distinctive
Credits/Recognition
6
Course disciplinary sector (SSD)
BIO/06 - comparative anatomy and cytology
Delivery
E-learning
Language
English
Attendance
Obligatory
Type of examination
Written and interview (optional)
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Sommario del corso

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Course objectives

This teaching contributes to the learning objectives included into the Neurobiological curriculum of the Master in Cellular and Molecular Biology - Biologia Cellulare e Molecolare, providing knowledge and applicative abilities in the study of the cellular and molecural bases of nervous system development. 

The main objective is to guide students to understand the genesis of the complexity of the nervous system, by developing research skills and critical readings of scientific papers dealing with different aspects of neural development. Through the analysis of the most recent literature based on different animal and in vitro models, the students will acquire knowledge on the principles and  cellular/molecular mechanisms  underlying normal development of the nervous system, as well as the neurobiological  bases of neurodevelopmental disorders. 

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Results of learning outcomes

KNOWLEDGE AND UNDERSTANDING

  • identify  fundamental concepts in developmental biology 
  • use appropriate terminology in developmental biology
  • explain the principles of  neural induction (molecular mechanisms and conservation among metazoa)
  • associate specific genes to acquisition of regional identity in the developing nervous system
  • define what is an organizing center in developing brain and provide examples
  • describe the cellular/molecular mechanisms underlying  neural circuit development
  • identify the features and potential of neural stem/progenitors cells and define their regulation by cell-autonomous vs non autonomous factors.
  • link specific cellular/molecular dysfunctions to neurodevelopmental disorders

 APPLYING KNOWLEDGE AND UNDERSTANDING

  • identify the best  model systems to address specific scientific questions in developmental neuroscience 
  • grasp the core concept of a scientific paper 
  • find and elaborate data related to gene expression/distribution in the developing nervous system starting from public availabe resources (i.e. Allen Brain Atlas)
  • find possible experimental approaches and choose the right technology to address specific questions in the field of developmental neuroscence
  • write a research project 

INDEPENDENT JUDGEMENT

  • interpretation and discussion of scientific data.
  • peer revision of other students tasks 

COMMUNICATION SKILLS

  • presentation of scientific papers and/or active participation to scientific discussion following lectures and seminars. 
  • presentation of a research project.
  • writing of short reports on scientific papers.

LEARNING SKILLS

  • learning skills will be fostered through activities with peers working in group 
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Program

 

Program

Introduction and basic knowledge in developmental biology; animal models, in vitro models and technologies for the study of nervous system development; neural induction, derivation of the nervous system in different metazoa, origin, role and molecular nature of the neural inducer; neural patterning, Hox genes and antero-posterior axis, dorso-ventral polarity of the neural tube; Cell proliferation and migration in the developing nervous tissue; Neural cell specification, determination and differentiation; Axon growth and guidance; Cerebral cortex development; Adult neurogenesisParticular emphasis will be given to new emerging technologies that can be applied synergistically to study any cell-tissue system development, such as single cell profiling, spatial transcriptomics, immunofluorescence and 3D imaging of optically cleared organs.

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Course delivery

 

 

The course is delivered in e-learning through the strat@unito platform https://start.unito.it/

Note that this online course does not include the module of the Visiting Professor

 

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Learning assessment methods

Tasks and activities during the course will be evaluated and the overall engagement of the students will weight 30% of the final grade.

Final exam (70% of the final grade) will be in presence on the moodle platform: it will consist in 10 closed questions and two questions based on topics covered in lectures, assigned readings, and online activities, followed by an oral examination (optional).

The final learning assessment(70% of the final grade) will be held in presence, in written form (Moodle platform). It will consist in 10 closed questions and two open questions based on topics covered in lectures, assigned readings, and online activities, with optional oral integration.

Exams will take place exclusively in presence

Remote examinations may be introduced according to the University recommendations.

IMPORTANT: Early registration to the e-learning platform (moodle) is mandatory !

Suggested readings and bibliography

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There is no specific textbook for this course. For basic and general reference, see Development of the Nervous System (D.H. Sanes, T.A. Reh, W. A. Harris) Academic Press - Elsevier, 4th Ed.

Specific scientific Articles and Reviews will be uploaded on the Moodle course website.

Websites containing support videos, texts, images and other materials are also indicated.



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Notes

Students that are enrolled in the online course should contact the teacher to receive specific instructions related to the updated programmed activities and integrations available on the moodle platform.

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