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Department of Life Sciences and Systems Biology

Cellular and Molecular Biology

Logo di Cellular and Molecular Biology

Simona Federica Spampinato

Associate Professor

Contacts

At

  • Dipartimento di Scienza e Tecnologia del Farmaco
  • Cellular and Molecular Biology
  • Corsi di studio in
    Farmacia - Chimica e tecnologia farmaceutiche
  • Corso di Laurea in Tecniche di Laboratorio Biomedico - Cuneo

Curriculum vitae

  • Curriculum Vitae (85.0 KB)

    • Selected research products

     

    • Spampinato SF, Costantino G, Merlo S, Canonico PL, Sortino MA Microglia Contributes to BAF-312 Effects on Blood–Brain Barrier Stability. Biomolecules 2022, 12, 1174. https:// doi.org/10.3390/biom12091174
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    • Spampinato SF, Takeshita Y, Obermeier B. An In Vitro Model of the Blood-Brain Barrier to Study Alzheimer's Disease: The Role of β-Amyloid and Its Influence on PBMC Infiltration. Methods in molecular biology (Clifton, N.J.), 2022, 2492, pp. 333–352
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    • Merlo S, Caruso GI   , Bonfili L, Spampinato SF   , Costantino G ,  Eleuteri AM, Sortino MA Microglial polarization differentially affects neuronal vulnerability to the β-amyloid protein: Modulation by melatonin Biochem Pharmacol . 2022 Jun 22;202:115151.doi: 10.1016/j.bcp.2022.115151.
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    • Spampinato SF, Sortino MA., Salomone S. Sphingosine-1-phosphate and Sphingosine-1-phosphate receptors in the cardiovascular system: pharmacology and clinical implications Advances in Pharmacologythis link is disabled, 2022, 94, pp. 95–139
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    • Rosa AC, Nardini P, Sgambellone S, Gurrieri M, Spampinato SF, Dell’Accio A, Chazot PL, Obara I, Liu WL Pini A (2022). CNS-Sparing Histamine H3 Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms Biomolecules, 12, 184. doi:10.3390/biom12020184
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    • Merlo S, Spampinato SF, Lim D. Molecular aspects of cellular dysfunction in Alzheimer’s disease: The need for a holistic view of the early pathogenesis. Biomolecules, 2021, 11(12), 1807
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    • Spampinato SF, Merlo S, Costantino G, Sano Y, Kanda T, Sortino MA (2021) Decreased astrocytic CCL2 accounts for BAF-312 effects on PBMCs transendothelial migration through a blood brain barrier in vitro model Journal of Neuroimmune Pharmacology, 10.1007/s11481-021-10016-5
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    • Caruso G.I., Spampinato S.F., Costantino G., Sortino M.A., Merlo S.(2021).SIRT1-Dependent upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin.  Biomedicines 2021, 9, 466.10.3390/biomedicines9050466
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    • Spampinato S. F., Merlo S., Sano Y., Kanda T., Sortino M. A. (2021). Protective effect of the sphingosine-1 phosphate receptor agonist siponimodon disrupted blood brain barrier function. Biochemical Pharmacology,vol. 186, 114465, ISSN:0006-2952, doi: 10.1016/j.bcp.2021.114465
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    • Merlo S., Luaces J. P., Spampinato S. F., Toro-Urrego N., Caruso G. I., D'amico F., Capani F., Sortino M. A. (2020). SIRT1 mediates Melatonin’s effects on microglial activation in hypoxia: In vitro and in vivo evidence. BIOMOLECULES, vol. 10, ISSN: 2218-273X,  doi: 10.3390/ biom10030364.
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    • Merlo S., Spampinato S.F., Caruso G.I., Sortino M.A. (2020). The ambiguous role of microglia in Aβ toxicity: Chances for therapeutic intervention. CURRENT NEUROPHARMACOLOGY, vol. 18, p. 446-455, ISSN: 1570-159X,  doi: 10.2174/1570159X18666200131105418
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    • Spampinato S.F., Merlo S., Fagone E., Fruciano M., Sano Y., Kanda T., Sortino M.A. (2020). Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid.   FRONTIERS IN MOLECULAR NEUROSCIENCE,  vol 13, 120,ISSN: 1662-5099,  eCollection 2020 doi: 10.3389/fnmol.2020.00120.

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    • Spampinato S.F., Caruso G.I., De Pasquale R., Sortino M.A, Merlo S. (2020). Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs.  PHARMACEUTICALS, vol. 13,60, ISSN: 1424-824,  doi: 10.3390/ph13040060

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    • Caruso G.  Fresta C.G., Musso N., Giambirtone M., Grasso M., Spampinato S.F., Merlo S., Drago F., Lazzarino G., Sortino M.A., Lunte S.M., Caraci F. (2019). Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1. CELLS, vol. 8, 64, ISSN: 2073-4409, doi: 10.3390/cells8010064

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    • Caruso G., Spampinato S.F., Cardaci V., Caraci F., Sortino M.A., Merlo S. (2019).β-amyloid and oxidative stress: perspectives in drug development. CURRENT PHARMACEUTICAL DESIGN, vol. 25, p. 4771-4781, ISSN: 1381-6128,  doi: 10.2174/1381612825666191209115431  

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    • Spampinato S.F., Bortolotto V., Canonico P.L., Sortino M.A., Grilli M.G. (2019). Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood-Brain Barrier Integrity FRONTIERS IN PHARMACOLOGY, vol 10,1346, ISSN: 1663-9812,

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    • Spampinato S. F., Merlo S., Fagone E., Fruciano M., Barbagallo C., Kanda T., Sano Y., Purrello M., Vancheri C., Ragusa M., Sortino M. A. (2019). Astrocytes modify migration of PBMCs induced by β-amyloid in a blood-brain barrier in vitro model.  FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 13, ISSN: 1662-5102,  doi: 10.3389/fncel.2019.00337

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    • Caraci F., Spampinato S.F., Morgese M.G., Tascedda F., Salluzzo M.G., Giambirtone M.C., Caruso G., Munafò A., Torrisi S.A., Leggio G.M., Trabace L., Nicoletti F., Drago F., Sortino M.A., Copani A. (2018). Neurobiological links between depression and AD: the role of TGF-β1 signaling as a new pharmacological target. PHARMACOLOGICAL RESEARCH, vol. 130, p. 374-384, ISSN: 1043-6618, doi: 10.1016/j.phrs.2018.02.007

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    • Merlo S., Spampinato S.F., Beneventano M., Sortino M.A. (2018). The contribution of microglia to early synaptic compensatory responses that precede ß-amyloid-induced neuronal death. SCIENTIFIC REPORTS, vol. 8, 7297, ISSN: 2045-2322,  doi: 10.1038/s41598-018-25453-1

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    • Merlo S., Spampinato S.F., Sortino M.A. (2018). Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease? CNS NEUROSCIENCE & THERAPEUTICS, vol. 25, p. 5-13, ISSN: 1755-5930, doi: 10.1111/cns.13050

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    • Spampinato S.F., Copani A., Nicoletti F., Sortino M.A., Caraci F. (2018). Metabotropic glutamate receptors in glial cells: A New Potential Target for Neuroprotection?  FRONTIERS IN MOLECULAR NEUROSCIENCE, vol. 11, 414, ISSN: 1662-5099,  doi: 10.3389/fnmol.2018.00414

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    • Beneventano M #., Spampinato S.F.#, Merlo S., Chisari M., Platania P., Ragusa M., Purrello M., Nicoletti F., Sortino M.A. (2017). Shedding of microvesicles from microglia contributes to the effects induced by metabotropic glutamate receptor 5 activation on neuronal death.  FRONTIERS IN PHARMACOLOGY, vol. 8, 812, ISSN: 1663-9812, doi: 10.3389/fphar.2017.00812

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    • Merlo S., Spampinato S.F., Sortino M.A. (2017). Estrogen and Alzheimer's disease: Still an attractive topic despite disappointment from early clinical results. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 817, p. 51-58,
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    • Spampinato S.F., Merlo S., Sano Y., Kanda T., Sortino M.A. (2017). Astrocytes contribute to Aβ-induced blood-brain barrier damage through activation of endothelial MMP9. JOURNAL OF NEUROCHEMISTRY, vol 142, 464-477, ISSN: 1471-4159, doi: 10.1111/jnc.14068.

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    • Takeshita Y., Obermeier B., Cotleur A.C., Spampinato S.F., Shimizu F., Yamamoto E., Sano Y., Kryzer T.J.,  Lennon V.A.,  Kanda T., Ransohoff  R.M. (2016). Effects of neuromyelitis optica–IgG at the blood–brain barrier in vitro.  Neurol Neuroimmunol Neuroinflamm. Vol 4, e311

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    • Caraci F., Tascedda F., Merlo S., Benatti C., Spampinato S.F., Munafò A., Leggio G.M., Nicoletti F., Brunello N., Drago F,. Sortino M.A., Copani A (2016)  Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1. Frontiers Pharmacology vol 7, 389 doi:10.3389/fphar.2016.00389. eCollection 2016.

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    • Merlo S., Spampinato S.F., Capani F., Sortino M.A. (2016). Early β-Amyloid-induced Synaptic  Dysfunction Is Counteracted by Estrogen in Organotypic Hippocampal Cultures. CURRENT ALZHEIMER RESEARCH,vol 13, 631-640 ISSN: 1567-2050 

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    • Prager B.#, Spampinato S.F.#, Ransohoff R.M. (2015). Sphingosine 1-phosphate signaling at the blood-brain barrier. TRENDS IN MOLECULAR MEDICINE, vol 21, 354-363, ISSN: 1471-4914,  doi: 10.1016/ j.molmed.2015.03.006 # Co-first authors.

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    • Spampinato S.F., Merlo S., Chisari M., Nicoletti F., Sortino M.A. (2015). Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. FRONTIERS IN CELLULAR NEUROSCIENCE, vol 8, 462, ISSN: 1662-5102, doi: 10.3389/fncel.2014.00462

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    • Sinagra T., Merlo S., Spampinato S.F., Di Pasquale R., Sortino M.A. (2015). High mobility group box 1 contributes to wound healing induced by inhibition of dipeptidylpeptidase 4  in cultured keratinocytes. FRONTIERS IN PHARMACOLOGY,  vol 6, 126, ISSN: 1663-9812  doi: 10.3389/fphar.2015.00126
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    • Spampinato S.F., Obermeier B., Cotleur A., Love A., Takeshita Y., Sano Y., Kanda T., Ransohoff R.M. (2015). Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli? PLOS ONE, vol 10, e0133392, ISSN: 1932-6203 doi:10.1371/journal.pone.0133392. eCollection 2015

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    • Caraci F., Battaglia G., Sortino M.A., Spampinato S.F., Molinaro G., Copani A., Nicoletti F., Bruno V.(2012). Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? NEUROCHEMISTRY INTERNATIONAL, vol. 61, p. 559-565, ISSN: 0197-0186,  

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    • Caraci F., Spampinato S.F., Sortino M.A., Bosco P., Battaglia G., Bruno V., Drago F., Nicoletti F., Copani A. (2012). Dysfunction of TGF-ß1 signaling in Alzheimer's disease: perspectives for neuroprotection. CELL AND TISSUE RESEARCH, vol. 341, p. 291-301, ISSN: 0302-766X
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    • Spampinato S.F., Merlo S., Molinaro G., Battaglia G., Bruno V., Nicoletti F., Sortino M.A. (2012). Dual Effect of 17-β-Estradiol on NMDA-Induced Neuronal Death: Involvement of Metabotropic Glutamate Receptor.  ENDOCRINOLOGY, vol 153, 5940-5948, ISSN: 0013-7227,  

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    • Spampinato S.F., Merlo S., Nicoletti F., Sortino M.A. (2012). A Main Role for Metabotropic Glutamate Receptor 1 in the Neuroprotective Effect of Estrogen.  MOLECULAR AND CELLULAR  PHARMACOLOGY, vol 4, 61-67, ISSN: 1938-1247

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    • Spampinato S.F., Molinaro G., Merlo S., Iacovelli L., Caraci F., Battaglia G., Nicoletti F., Bruno V., Sortino M.A. (2012). Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against ß-amyloid toxicity. MOLECULAR PHARMACOLOGY, vol. 81, p. 12-20, ISSN: 0026-895X,  doi: 10.1124/mol.111.074021.

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    • Spampinato S.F.# Trabucco A.#, Biasiotta A., Biagioni F., Cruccu G., Copani A., Colledge W.H., Sortino M.A., Nicoletti F., Chiechio S. (2011). Hyperalgesic activity of kisspeptin in mice.  MOLECULAR PAIN, vol. 7, 90,  ISSN: 1744-8069,  doi: 10.1186/1744-8069-7-90. # Co-first authors

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    • Merlo S., Spampinato S.F., Canonico P.L., Copani A., Sortino M.A. (2010). Alzheimer's disease: brain expression of a metabolic disorder?  TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol. 21, p. 537-544 doi: 10.1016/j.tem.2010.05.005

     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
      
     

    Courses

    Research topics

    The main research efforts are in the study of pathophysiological mechanisms involved in neurodegenerative and neuroinflammatory disorders.

    A particular attention is drawn on the properties and functions of the blood brain barrier (BBB), considered as potential pharmacological target in the diseases of the central nervous system and the crosstalk occurring between endothelial cells and glial cells (astrocytes and microglia). 

    Research groups

    Activities in agenda

    See my calendar

    Academic bodies

    Office hours

    Previo appuntamento tramite e-mail all'indirizzo: simonafederica.spampinato@unito.it

    Receipt by prior arrangement by mail: simonafederica.spampinato@unito.it

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