Vai al contenuto principale
Coronavirus: aggiornamenti per la comunità universitaria / Coronavirus: updates for UniTo Community
Oggetto:
Oggetto:

DEVELOPMENTAL NEUROBIOLOGY

Oggetto:

DEVELOPMENTAL NEUROBIOLOGY

Oggetto:

Academic year 2017/2018

Course ID
SVB0064
Teacher
Prof. Silvia De Marchis
Degree course
Cellular and Molecular Biology
Year
1st year
Teaching period
Second semester
Type
Distinctive
Credits/Recognition
6
Course disciplinary sector (SSD)
BIO/06 - anatomia comparata e citologia
Delivery
Blended
Language
English
Attendance
Lessons optional and laboratories mandatory
Type of examination
Written and interview (optional)
Prerequisites
Basic knowledges of developmental biology and citology/histology of the nervous system.
Oggetto:

Sommario del corso

Oggetto:

Course objectives

This course contributes to the learning goals of the Neurobiological curriculum of the Master in Cellular and Molcula Biology. 

The main objective is to guide students to understand the genesis of the complexity of the nervous system, by developing research skills and critical readings of scientific papers dealing with different aspects of neural development. Through the analysis of the most recent literature based on different animal and in vitro models, the students will acquire knowledge on the principles and  cellular/molecular mechanisms  underlying normal development of the nervous system, as well as the neurobiological  bases of neurodevelopmental disorders. 

Oggetto:

Results of learning outcomes

KNOWLEDGE AND UNDERSTANDING

  • identify  fundamental concepts in developmental biology 
  • use appropriate terminology in developmental biology
  • explain the principles of  neural induction (molecular mechanisms and conservation among metazoa)
  • associate specific genes to acquisition of regional identity in the developing nervous system
  • define what is an organizing center in developing brain
  • describe the cellular/molecular mechanisms underlying  neural circuit development
  • identify the features and potential of neural stem/progenitors cells and define their regulation by cell-autonomous vs non autonomous factors.
  • link specific cellular/molecular dysfunctions to neurodevelopmental disorders

 APPLYING KNOWLEDGE AND UNDERSTANDING

  • identify the best  model systems to address specific scientific questions in developmental neuroscience 
  • grasp the core concept of a scientific paper 
  • find and elaborate data related to gene expression/distribution in the developing nervous system starting from public availabe resources (i.e. Allen Brain Atlas)
  • find possible experimental approaches and choose the right technology to address specific questions in the field of developmental neuroscence

INDEPENDENT JUDGEMENT

  • interpretation and discussion of scientific data.
  • peer revision of other students tasks 

COMMUNICATION SKILLS

  • discussion  of scientific papers and/or active participation to scientific discussion following lectures and seminars.
  • organization of a student's workshop focused on the last frontiers in developmental neuroscience (presentation given by the students). 

LEARNING SKILLS

  • learning skills will be fostered through activities with peers working in group 
Oggetto:

Course delivery

During the course  there will be lecture-based classes to introduce the main questions and established knowledge in the field, but the students will be encouraged to be actively engaged through the organization of small groups to discuss material (mainly current research papers) for each topic.  Specific readings and online activities  on moodle platform will be assigned to the students and monitored by the teacher. 

Oggetto:

Learning assessment methods

Tasks and activities during the course will be evaluated and will weight 30% of the final grade.

Final exam (70% of the final grade) will be on the moodle platform:  it will consist in open questions based on topics covered in lectures, assigned readings, and online activities. Upon student's request, an integrative oral examination can be taken (written/oral: 1/1).

IMPORTANT: Early registration to the e-learning platform (moodle) is mandatory !

Oggetto:

Program

Introduction and basic knowledge in developmental biology; animal models, in vitro models and technologies for the study of nervous system development; neural induction, derivation of the nervous system in different metazoa, origin, role and molecular nature of the neural inducer; neural patterning, Hox genes and antero-posterior axis, dorso-ventral polarity of the neural tube; Cell proliferation and migration in the developing nervous tissue; Neural cell specification, determination and differentiation; Axon growth and guidance; Synapse formation and refinement; Cerebral cortex development; Adult neurogenesis.

Suggested readings and bibliography

Oggetto:

There is no specific textbook for this course. For basic and general reference, see Development of the Nervous System (D.H. Sanes, T.A. Reh, W. A. Harris) Academic Press - Elsevier, 3rd Ed.

Specific scientific Articles and Reviews will be uploaded on the Moodle course website.

Websites containing support videos, texts, images and other materials are also indicated.



Oggetto:

Class schedule

Notes: See the timetable at the Class Schedule Page

Oggetto:
Last update: 05/03/2018 19:16
Non cliccare qui!