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MOLECULAR PHARMACOLOGY
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MOLECULAR PHARMACOLOGY
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Academic year 2015/2016
- Course ID
- SVB0043
- Teaching staff
- Prof. Carlo FERRETTI
Dott. Loredana SERPE - Degree course
- Cellular and Molecular Biology
- Year
- 1st year
- Teaching period
- Second semester
- Type
- Distinctive
- Credits/Recognition
- 6
- Course disciplinary sector (SSD)
- BIO/14 - farmacologia
- Delivery
- Formal authority
- Language
- English
- Attendance
- Lessons optional and laboratories mandatory
- Type of examination
- Written
- Prerequisites
- Basic Knowledge of Anatomy, Biohemistry, Cellular and Molecular Biology, Physiology and Pathology.
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Sommario del corso
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Course objectives
- Core and advanced Knowledge of the fundamental principles of drug action at the molecular level, through which students will be able to connect the action of selected groups of clinically important drugs with body's responses
- Drug knowledge not only as a therapeutic tool but also as a research tool, so students will be able to understand preclinical and clinical research strategies for drug development
- Scientific thinking through the development of students' critical analysis skills, so students will be able to understand experimental approaches and data of scientific literature improving their knowledge as well as their research skills.
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Results of learning outcomes
- Understanding of drug principles and molecular targets of selected groups of clinically important drugs
- Practical experience of pharmacokinetic/ pharmacodynamic studies
- Research skills to characterize drug action
- Pre-clinical and clinical strategies for drug discovery and development.
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Course delivery
The course consists of:
- 36 teaching hours to provide core knowledge of the different topics covered
- 12 hours of group activities for students discussing scientific literature on pharmacological topics of interest.
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Learning assessment methods
The examination consists of a written test with 30 multiple choice questions (max 27/30) and one open question (max 3/30) to evaluate the understanding of basic principles of Pharmacology and the student ability to correlate molecular mechanisms and drug response.
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Program
Part I - General Pharmacology
- Drug discovery and development
- Pharmacokinetics
- drug absorption, distribution, metabolism and elimination
- Pharmacodynamics
- agonism and antagonism, quantifying methods
- pharmacological modulation of receptor-mediated responses, molecular mechanisms of receptor up-/down-regulation
Part II - Special Pharmacology - selected groups of clinically important drugs will be studied with respect to the mechanism of action at the molecular level
- Modulation of cardiovascular function (anti-hypertensive drugs; anticoagulant, fibrinolytic and antiplatelet drugs; drug therapy for hypercholesterolemia and dyslipidemia)
- Modulation of endocrine function (pharmacotherapy of diabetes)
- Modulation of pain (corticosteroids, non-steroidal anti-inflammatory drugs, opioids)
- Neuropharmacology (pharmacotherapy of neurodegenarative disorders)
- Cancer pharmacology (cytotoxic agents, natural products, hormones and related agents, tyrosine kinase inhibitors, monoclonal antibodies and cytokines).
Suggested readings and bibliography
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- Teaching Materials:
"Molecular Pharmacolgy" at UniTo website
- Reference Books:
Katzung "Basic & Clinical Pharmacology" Mc Graw Hill Ed.
Rang & Dale "Pharmacology" Elsevier Ed.
Goodman & Gilman's "The pharmacological basis of therapeutics" Mc Graw Hill Ed.
- Websites of Interest:
http://www.nature.com/pharma - http://www.ncbi.nlm.nih.gov - http://www.bps.ac.uk - http://farmacologiasif.unito.it
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Class schedule
Days Time Classroom Lessons: from 29/02/2016 to 10/06/2016 Notes: See the timetable at the Class Schedule Page
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