NICO-Webinar: "Neuroendocrinology of social cognition in female and male mice?" 17/3/23 @ 14.00
Elena Choleris, Department of Psychology and Neuroscience Program, University of Guelph, Ontario, Canada
Neuroendocrinology of social cognition in female and male mice
Recent findings demonstrate rapid hormonal facilitation of social cognition in various brain regions of female a male mice. In females, in the Dorsal Hippocampus estradiol’s rapid facilitating effects are broad across multiple (but not all tested) learning tasks. In the Paraventricular Nucleus of the Hypothalamus (PVN), Medial Amygdala (MeA) and Medial Prefrontal Cortex, instead, the effects appear specific to social cognition, other types of learning tasks being unaffected. In the PVN and MeA those effects depend upon the action of MeA oxytocin receptors and do not extend to males. In males, in the Bed Nucleus of the Stria Terminalis, estradiol, testosterone and dihydrotestosterone all rapidly facilitate social recognition while inversely affecting object recognition, and those effects depend upon Arginine Vasopressin receptors V1aR in the Lateral Septum. Together, these investigations are highlighting the rapid hormonal regulation of brain networks of females and males subserving social cognition, further advancing our understanding of hormonal regulation of the social brain.
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