NICO-Webinar: "The scent-sational role of GnRH neurons" 10/3/23 @ 14.00
Friday 10/3/23 h. 2:00 pm -
Paolo Giacobini, INSERM Research Director, Lille Neuroscience & Cognition
Development and Plasticity of the Neuroendocrine Brain
The scent-sational role of GnRH neurons
Gonadotropin-releasing hormones (GnRH) neurons are the master regulators of fertility in vertebrates. Hypothalamic GnRH-secreting neurons release their hormone through the median eminence (ME) into the hypophyseal portal system to stimulate the production and release of pituitary gonadotropins, which regulate the development and function of the gonads. To ensure reproductive success, GnRH neurons have to process and integrate various internal and external cues to elicit the most adapted neuroendocrine responses. We recently identified, both in mice and humans, a sub-population of extra-hypothalamic GnRH neurons located in the olfactory bulb (OB), whose role has never been investigated. Combining mouse genetics with Cre-dependent viral tracing approaches, and 3D-imaging of whole-mouse heads, we revealed that OB-GnRH neurons project neurites contacting the vomeronasal organ, the chemosensory system that perceives and processes stimuli related to social and reproductive behaviors in many species of vertebrates. In addition, OB-GnRH neurons send long projections to the hypothalamic areas involved in the control of gonadotropin release. Bidirectional chemogenetic neuromodulation combined with behavioral testing, electrophysiological recording and two-photon in vivocalcium-imaging, demonstrated a novel role for this extra-hypothalamic GnRH neuronal population as a central regulatory hub linking pheromonal stimulation with the neuroendocrine response regulating reproduction and mating behavior.
Host: Silvia De Marchis | webex link