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CELLULAR NEUROBIOLOGY

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CELLULAR NEUROBIOLOGY

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Academic year 2021/2022

Course ID
SVB0069
Teacher
Prof. Patrizia Bovolin (Coordinator)
Degree course
Cellular and Molecular Biology
Year
1st year
Teaching period
Semester 1
Type
Distinctive
Credits/Recognition
5
Course disciplinary sector (SSD)
BIO/06 - anatomia comparata e citologia
Delivery
Blended
Language
English
Attendance
Optional
Type of examination
Interview
Propedeutic for
Developmental Neurobiology
Neurophysiology
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Sommario del corso

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Course objectives

This teaching is in-line with the learning goals of the Neurobiology track of the Master in Cellular and Molecular Biology.  The main objective is to provide students with an advanced knowledge of cell and molecular biology of neurons, glia and other neural cell types and to make students able to apply this knowledge to specific aspects of brain function

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Results of learning outcomes

KNOWLEDGE AND UNDERSTANDING

  • familiarize with the concept of the relationship between the structure of the different subcellular structures of neurons and glial cells and their physiological roles with emphasys on the molecular mechanisms
  • describe and understand the origin and function of cell type multiplicity in the nervous system, with special emphasys on cortical interneuron subtypes

APPLYING KNOWLEDGE AND UNDERSTANDING

  • The students will familiarize with techniques and research strategies employed in cellular neurobiology, including cell culture techniques for specific neural cell types
  • They will improve their comprehension of scientific articles and develop their skills in choosing, reporting and discussing data from the neurobiology scientific literature
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Program

  • Ependymal, choroidal and endothelial cells: BBB, B-CSF-B, the problem of delivery of exogenous molecules to the brain
  • The neuron: origin and function of neuronal multiplicity - subcellular organization of the neuron
  • Glial cells: -new and classical roles - Astrocytes: morphological & functional features, reactive gliosis, gliotransmission - Microglia: physiological and pathological roles.
  • Cellular communication in the nervous system: the neuron as a secretory cell - functional organization of the pre- and postsynaptic terminals - neurotransmitters and neuromodulators - structure and function of the main neurotransmitter receptors - dynamic regulation of gabaergic and glutamatergic synapses - the endocannabinoid system - non-synaptic communication
  • EXPERT SECTION (delivered by a visiting professor) The Zebrafish model in Neurobiology - Anatomical organization and molecular mechanisms of the circadian clock system in vertebrates - Neuroendocrine regulation of food consumption and associated pathological aspects from fish to mammals
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Course delivery

  • Teaching includes 40 hours of lectures and seminars, interactive group work, discussion times and short movies
  • The EXPERT SECTION includes lessons and seminars delivered by a visiting professor on specific topics
  • The teacher will select four-five articles per topic, among all the ones proposed by the students, for end-of-the-course student ppt presentations
Due the COVID-19 health emergency, for the academic year 2021-22 lessons and all other live activities will be both delivered in a classroom (except in case of sanitary restriction) and over the Internet in live streaming through a WebEx Virtual Room; lessons and seminars will be also recorded and made accessible on the Moodle teaching platform, together with all other teaching material
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Learning assessment methods

  • Bibliographic search activity (obligatory): For each main topic presented by the teacher in lecture form, all the students will make a bibliographic search on PubMed/Google Scholar to find one research article, which should be interesting and pertinent to the topic
  • Short article presentation (optional): Students will give a short ppt presentation before the end of the lessons on one of the articles previously selected through the Biobliographic Search activity. This presentation may provide additional points to the grade of the final exam, provided this will be passed in the first exam session (January-February 2022)
  • Final exam: This exam will consist of an oral colloquium either in class or, if the COVID-19 health emergency will persist, in remote modality by connecting in Virtual Room (WebEx). This colloquium will consist of a discussion on the topics covered in lectures, seminars, assigned readings and movies.
  • Scores: 25% of the final grade will be based on the Bibliographic Search activity. The remaining 75% will be covered by the final exam. The maximum grade will be 32/30. "30 cum laude" will be assigned to grades 31 and 32. All additional points obtained with the PPT presentation will be added to the final exam of the first exam session (January-February 2022).

Suggested readings and bibliography

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  • Neurobiology: a functional approach - Striedter (2016)
  • Neuroscience - Purves et al. (2018 sixth edition)
  • Principles of Neural Sciences - Kandel et al.  (2013 fifth edition)
  • Scientific articles indicated in the teaching material


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Courses that borrow this teaching

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Class scheduleV

Notes: See the timetable at the Class Schedule Page

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