Cellular and Molecular Biology

Research products

Courses

• BIOCHIMICA STRUTTURALE E FUNZIONALE (CHI0047)
  Corso di laurea magistrale in Chimica
• LABORATORIO BIOMOLECOLARE (SVB0029)
  Corso di laurea in Scienze Biologiche (L-13)
• LABORATORIO BIOMOLECOLARE (non attivato nel 2016/17) (MFN1294)
  Corso di laurea in Scienze Biologiche (L-13)
• METABOLIC BIOCHEMISTRY (SVB0042)
  Cellular and Molecular Biology
• STRUCTURE OF MACROMOLECULES AND PROTEOMICS (SVB0049)
  Cellular and Molecular Biology
• STRUTTURISTICA DI BASE DI MACROMOLECOLE (SVB0029C)
  Corso di laurea in Scienze Biologiche (L-13)
• STRUTTURISTICA DI BASE DI MACROMOLECOLE (MFN1294B)
  Corso di laurea in Scienze Biologiche (L-13)

Research topics

For full information on the Research Group please visit:  http://www.biochemistry-scienze.unito.it

The research of Dr. Di Nardo focuses on the structure-function relationship of human aromatase, the enzyme converting androgens into estrogens, with a particular enphasis to its role in the brain and in estrogen-dependent tumors. The project aims to elucidate how the activity of this enzyme is regulated by post-translational modifications, by drugs and xenobiotics starting the study from the molecular level up to cellular models, in close collaboration with different research groups.

The methodologies used range from spectroscopy (UV-vis, IR, circular dichroism and fluorescence) to x-ray crystallography.

Research groups

• Discovery and Engineering of New Biocatalysts for Bioremediation
• Drug metabolising Enzymes

• Enzimi del metabolismo dei farmaci
• Identificazione e ingegnerizzazione di nuovi biocatalizzatori per il biorisanamento

Activities in agenda

See my calendar

Academic bodies

• Commissione per la Didattica
• Department Board

• Commissione per la Didattica
• Consiglio di Dipartimento
• Giunta

• Foreign Degree Recognition
• Monitoring and Review Committee

• 8. Comitato di Indirizzo e Consultazioni Parti Interessate

Office hours

Thesis, work placement and internship offers

• Functional and structural characterization of a novel cytochrome P450 from the cyanobacterium Stanieria cyanosphaera.
• Engineering of Fluorescent Biosensor for Drug Screening
• Role of protein phase separation in the pathophysiology of the nervous system
• Structural and functional dynamics of memory-related neuronal proteins
• Insecticide “greening” by developing natural inhibitors for insect cytochromes P450.
• Human cytochrome CYP4 modifications by malarial lipoperoxidation product 4-hydroxynonenal (4-HNE): the role in malaria immunosuppression
• Role of endothelium in the development of arterial vs. venous thrombosis in auto-immunity

member of tutors