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DEVELOPMENTAL NEUROBIOLOGY
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DEVELOPMENTAL NEUROBIOLOGY
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Academic year 2016/2017
- Course ID
- SVB0064
- Teacher
- Prof. Silvia De Marchis
- Degree course
- Cellular and Molecular Biology
- Year
- 1st year
- Teaching period
- Second semester
- Type
- Distinctive
- Credits/Recognition
- 6
- Course disciplinary sector (SSD)
- BIO/06 - anatomia comparata e citologia
- Delivery
- Blended
- Language
- English
- Attendance
- Lessons optional and laboratories mandatory
- Type of examination
- Written and oral (optional)
- Prerequisites
- Basic knowledges of developmental biology and citology/histology of the nervous system.
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Sommario del corso
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Course objectives
The main goal is to guide students to understand the genesis of the complexity of the nervous system, by developing research skills and critical readings of scientific papers dealing with different aspects of neural development. Through the analysis of the most recent literature based on different anmal and in vitro models, the students will acquire knowledge on the principles and cellular/molecular mechanisms underlying normal development of the nervous system, as well as the neurobiological bases of neurodevelopmental disorders.
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Results of learning outcomes
KNOWLEDGE AND UNDERSTANDING
- neural induction
- neural patterning
- neural progenitors potential and differentiation
- neuronal circuits development
- main technical and experimental approaches
APPLYING KNOWLEDGE AND UNDERSTANDING
- ability to grasp the core concept of a scientific problem in the field of developmental neurobiology
- ability to find appropriate experimental approaches to address a specific question in the field
- ability to find and elaborate data related to gene expression/distribution in the developing nervous system starting from public availabe resources (i.e. Allen Brain Atlas)
INDEPENDENT JUDGEMENT
- interpretation and discussion of scientific data.
COMMUNICATION SKILLS
- discussion and presentation of scientific papers and/or active participation to scientific discussion following seminars
LEARNING SKILLS
- learning skills will be fostered through activities with peers working in group
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Course delivery
During the course there will be mainly lecture-based classes to introduce the main questions and established knowledge in the field, but the students will be encouraged to be actively engaged through the organization of small groups to discuss material (mainly current research papers) for each topic. Specific readings and online activities on moodle platform will be assigned to the students and monitored by the teacher.
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Learning assessment methods
Examinations will be based on material covered in lectures, assigned readings, and online activities.
Final exam will be on the moodle platform: it will consist in 3 open questions.
Upon student’s request, an integrative oral examination can be taken (written/oral: 1/1).
IMPORTANT: Early registration to the e-learning platform (moodle) is mandatory !
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Program
Neural induction; Polarity and segmentation; Cell proliferation and migration in the developing nervous tissue; Neural cell specification, determination and differentiation; Axon growth and guidance; Synapse formation and refinement; Adult neurogenesis.
Suggested readings and bibliography
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There is no specific textbook for this course. For basic and general reference, see Development of the Nervous System (D.H. Sanes, T.A. Reh, W. A. Harris) Academic Press – Elsevier, 3rd Ed.
Specific scientific Articles and Reviews are posted on the Moodle course website.
Websites containing support videos, texts, images and other materials are also indicated.
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Class schedule
Notes: See the timetable at the Class Schedule Page
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