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Department of Life Sciences and Systems Biology

Cellular and Molecular Biology

Logo di Cellular and Molecular Biology

Giulio Ferrero

(RTDb) Assistant Professor

Contacts

At

  • Dipartimento di Scienze Cliniche e Biologiche
  • Cellular and Molecular Biology
  • Corso di Laurea in Biotecnologie
  • MedInTO Medicine and Surgery

Curriculum vitae

  • Curriculum Vitae (0.2 MB)

    • Research products

    All my research products

    Selected research products

    Ferrero G, Cardamone MD, Luca F, Bourk E, Ricci L, Liu W, Gao Y, Burrone G, Muhammad A, Chan S, Smith E, Fan TC, Cutrupi S, Garcia-Bassets I, De Bortoli M, Rosenfeld MG, Perissi V. (2025) Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America 122(18) e2502805122 [DOI  PMID]

    Omezzolli G, Iannello A, Vallone FE, Brandimarte L, Micillo M, Bertola N, Lavarello C, Grinovero N, Ferrero G, Mellert K, Moller P, Bruno S, Furman RR, Allan JN, Petretto A, Deaglio S, Ravera S, Vaisitti T. (2025) Complementary approaches define the metabolic features that accompany Richter syndrome transformation. Cellular and molecular life sciences : CMLS 82(1) 152 [DOI  PMID]

    Camandona A, Gagliardi A, Licheri N, Tarallo S, Francescato G, Budinska E, Carnogurska M, Zwinsova B, Martinoglio B, Franchitti L, Gallo G, Cutrupi S, De Bortoli M, Pardini B, Naccarati A, Ferrero G. (2025) Multiple regulatory events contribute to a widespread circular RNA downregulation in precancer and early stage of colorectal cancer development. Biomarker research 13(1) 30 [DOI  PMID]

    Schiavon A, Saba L, Evaristo C, Petiti J, Pignochino Y, Ferrero G, et al. (2025) Mitotane activates ATF4/ATF3 axis triggering endoplasmic reticulum stress in adrenocortical carcinoma cells. Biomedicine & pharmacotherapy 184 117917 [DOI  PMID]

    Macwan RS, Ferrero G, et al. (2025) TPM4 overexpression drives colon epithelial cell tumorigenesis by suppressing differentiation and promoting proliferation. Neoplasia (New York, N.Y.) 59 101093 [DOI  PMID]

    Daveri E, Vergani B, Lalli L, Ferrero G, et al. (2024) Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis. Journal for immunotherapy of cancer 12(10) [DOI  PMID]

    Cirillo E, Tarallo A, Toriello E, Carissimo A, Giardino G, De Rosa A, Damiano C, Soresina A, Badolato R, Dellepiane RM, Baselli LA, Carrabba M, Fabio G, Bertolini P, Montin D, Conti F, Romano R, Pozzi E, Ferrero G, et al. (2024) MicroRNA dysregulation in ataxia telangiectasia. Frontiers in immunology 15 1444130 [DOI  PMID]

    Naccarati A, Dragomir MP, Tarallo S, Gagliardi A, Alberini V, Buchler T, Liska V, Gallo G, Vymetalkova V, Vodickova L, Vodicka P, Pardini B, Ferrero G. (2024) Fecal miRNA profiles in colorectal cancers with mucinous morphology. Mutagenesis [DOI  PMID]

    Illescas O, Ferrero G, et al. (2024) Modulation of faecal miRNAs highlights the preventive effects of a Mediterranean low-inflammatory dietary intervention. Clinical nutrition (Edinburgh, Scotland) 43(4) 951-959 [DOI  PMID]

    Ferrero G, et al. (2024) Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells. Molecular medicine (Cambridge, Mass.) 30(1) 12 [DOI  PMID]

    Pastorino GA, Sheraj I, Huebner K, Ferrero G, et al. (2024) A partial epithelial-mesenchymal transition signature for highly aggressive colorectal cancer cells that survive under nutrient restriction. The Journal of pathology 262(3) 347-361 [DOI  PMID]

    Boretto C, Actis C, Faris P, Cordero F, Beccuti M, Ferrero G, et al. (2023) Tamoxifen Activates Transcription Factor EB and Triggers Protective Autophagy in Breast Cancer Cells by Inducing Lysosomal Calcium Release: A Gateway to the Onset of Endocrine Resistance. International journal of molecular sciences 25(1) [DOI  PMID]

    Picchio V, Ferrero G, et al. (2024) Effect of traditional or heat-not-burn cigarette smoking on circulating miRNAs in healthy subjects. European journal of clinical investigation 54(4) e14140 [DOI  PMID]

    Pardini B, Ferrero G, Naccarati A. (2024) Reply. Gastroenterology 166(2) 358-359 [DOI  PMID]

    Birkeland E, Ferrero G, et al. (2023) Profiling small RNAs in fecal immunochemical tests: is it possible? Molecular cancer 22(1) 161 [DOI  PMID]

    Pardini B, Ferrero G, et al. (2023) A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study. Gastroenterology 165(3) 582-599.e8 [DOI  PMID]

    Francavilla A, Ferrero G, et al. (2023) Gluten-free diet affects fecal small non-coding RNA profiles and microbiome composition in celiac disease supporting a host-gut microbiota crosstalk. Gut microbes 15(1) 2172955 [DOI  PMID]

    Gagliardi A, Francescato G, Ferrero G, et al. (2023) The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients. Cancer medicine 12(5) 5859-5873 [DOI  PMID]

    Merlini A, Centomo ML, Ferrero G, et al. (2022) DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination. Frontiers in oncology 12 844250 [DOI  PMID]

    Berrino E, Annaratone L, Bellomo SE, Ferrero G, et al. (2022) Integrative genomic and transcriptomic analyses illuminate the ontology of HER2-low breast carcinomas. Genome medicine 14(1) 98 [DOI  PMID]

    Elhasnaoui J, Ferrero G, et al. (2022) A Regulatory Axis between Epithelial Splicing Regulatory Proteins and Estrogen Receptor alpha Modulates the Alternative Transcriptome of Luminal Breast Cancer. International journal of molecular sciences 23(14) [DOI  PMID]

    Moisoiu T, Dragomir MP, Iancu SD, Schallenberg S, Birolo G, Ferrero G, et al. (2022) Combined miRNA and SERS urine liquid biopsy for the point-of-care diagnosis and molecular stratification of bladder cancer. Molecular medicine (Cambridge, Mass.) 28(1) 39 [DOI  PMID]

    Elhasnaoui J, Ferrero G, et al. (2021) The Estrogen Receptor alpha Signaling Pathway Controls Alternative Splicing in the Absence of Ligands in Breast Cancer Cells. Cancers 13(24) [DOI  PMID]

    Giordano G, Merlini A, Ferrero G, et al. (2021) EphA2 Expression in Bone Sarcomas: Bioinformatic Analyses and Preclinical Characterization in Patient-Derived Models of Osteosarcoma, Ewing's Sarcoma and Chondrosarcoma. Cells 10(11) [DOI  PMID]

    Francavilla A, Gagliardi A, Piaggeschi G, Tarallo S, Cordero F, Pensa RG, Impeduglia A, Caviglia GP, Ribaldone DG, Gallo G, Grioni S, Ferrero G, et al. (2021) Faecal miRNA profiles associated with age, sex, BMI, and lifestyle habits in healthy individuals. Scientific reports 11(1) 20645 [DOI  PMID]

    Tarallo S, Ferrero G, et al. (2022) Stool microRNA profiles reflect different dietary and gut microbiome patterns in healthy individuals. Gut 71(7) 1302-1314 [DOI  PMID]

    Ferrero G, et al. (2021) Computational Analysis of circRNA Expression Data. Methods in molecular biology (Clifton, N.J.) 2284 181-192 [DOI  PMID]

    Ferrero G, et al. (2020) Intake of Natural Compounds and Circulating microRNA Expression Levels: Their Relationship Investigated in Healthy Subjects With Different Dietary Habits. Frontiers in pharmacology 11 619200 [DOI  PMID]

    Mandili G, Curcio C, Bulfamante S, Follia L, Ferrero G, et al. (2020) In pancreatic cancer, chemotherapy increases antitumor responses to tumor-associated antigens and potentiates DNA vaccination. Journal for immunotherapy of cancer 8(2) [DOI  PMID]

    Godel M, Morena D, Ananthanarayanan P, Buondonno I, Ferrero G, et al. (2020) Small Nucleolar RNAs Determine Resistance to Doxorubicin in Human Osteosarcoma. International journal of molecular sciences 21(12) [DOI  PMID]

    Elhasnaoui J, Miano V, Ferrero G, et al. (2020) DSCAM-AS1-Driven Proliferation of Breast Cancer Cells Involves Regulation of Alternative Exon Splicing and 3'-End Usage. Cancers 12(6) [DOI  PMID]

    Mandili G, Follia L, Ferrero G, et al. (2020) Immune-Complexome Analysis Identifies Immunoglobulin-Bound Biomarkers That Predict the Response to Chemotherapy of Pancreatic Cancer Patients. Cancers 12(3) [DOI  PMID]

    Ferrero G, et al. (2019) Docker4Circ: A Framework for the Reproducible Characterization of circRNAs from RNA-Seq Data. International journal of molecular sciences 21(1) [DOI  PMID]

    Tarallo S, Ferrero G, et al. (2019) Altered Fecal Small RNA Profiles in Colorectal Cancer Reflect Gut Microbiome Composition in Stool Samples. mSystems 4(5) [DOI  PMID]

    Thomas AM, Manghi P, Asnicar F, Pasolli E, Armanini F, Zolfo M, Beghini F, Manara S, Karcher N, Pozzi C, Gandini S, Serrano D, Tarallo S, Francavilla A, Gallo G, Trompetto M, Ferrero G, et al. (2019) Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation. Nature medicine 25(4) 667-678 [DOI  PMID]

    Follia L, Ferrero G, et al. (2019) Integrative Analysis of Novel Metabolic Subtypes in Pancreatic Cancer Fosters New Prognostic Biomarkers. Frontiers in oncology 9 115 [DOI  PMID]

    Iannello A, Rolla S, Maglione A, Ferrero G, et al. (2018) Pregnancy Epigenetic Signature in T Helper 17 and T Regulatory Cells in Multiple Sclerosis. Frontiers in immunology 9 3075 [DOI  PMID]

    Kulkarni N, Alessandri L, Panero R, Arigoni M, Olivero M, Ferrero G, et al. (2018) Reproducible bioinformatics project: a community for reproducible bioinformatics analysis pipelines. BMC bioinformatics 19(Suppl 10) 349 [DOI  PMID]

    Miglio U, Berrino E, Panero M, Ferrero G, et al. (2018) The expression of LINE1-MET chimeric transcript identifies a subgroup of aggressive breast cancers. International journal of cancer 143(11) 2838-2848 [DOI  PMID]

    Coscujuela Tarrero L, Ferrero G, et al. (2018) Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Oncotarget 9(18) 14580-14596 [DOI  PMID]

    Miano V, Ferrero G, et al. (2018) Luminal lncRNAs Regulation by ERalpha-Controlled Enhancers in a Ligand-Independent Manner in Breast Cancer Cells. International journal of molecular sciences 19(2) [DOI  PMID]

    Ferrero G, et al. (2018) Small non-coding RNA profiling in human biofluids and surrogate tissues from healthy individuals: description of the diverse and most represented species. Oncotarget 9(3) 3097-3111 [DOI  PMID]

    Ferrero G, et al. (2017) Dissecting the genomic activity of a transcriptional regulator by the integrative analysis of omics data. Scientific reports 7(1) 8564 [DOI  PMID]

    Guglielmotto M, Reineri S, Iannello A, Ferrero G, et al. (2016) E2 Regulates Epigenetic Signature on Neuroglobin Enhancer-Promoter in Neuronal Cells. Frontiers in cellular neuroscience 10 147 [DOI  PMID]

    Rosso MC, Badino P, Ferrero G, et al. (2016) Biologic Data of Cynomolgus Monkeys Maintained under Laboratory Conditions. PloS one 11(6) e0157003 [DOI  PMID]

    Miano V, Ferrero G, et al., (2016) Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer. Oncotarget 7(3) 3201-16 [DOI  PMID]

    Cordero F, Ferrero G, et al. (2015) Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort. Carcinogenesis 36(10) 1144-53 [DOI  PMID]

    Misale C, Ferrero G, et al. (2014) Sequence alignment tools: one parallel pattern to rule them all? BioMed research international 2014 539410 [DOI  PMID]

    Caizzi L, Ferrero G, et al. (2014) Genome-wide activity of unliganded estrogen receptor-alpha in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America 111(13) 4892-7 [DOI  PMID]

    Cutrupi S, Ferrero G, et al. (2014) Genomic lens on neuroglobin transcription. IUBMB life 66(1) 46-51 [DOI  PMID]

    Courses

    Research topics

    Italiano

    Il Dott. Ferrero è ricercatore presso il Dipartimento di Scienze Cliniche e Biologiche. Il conseguimento della Laurea Magistrale in Biologia Cellulare e Molecolare e del Dottorato in Sistemi Complessi per le Scienze della Vita (Università di Torino) ha consentito al Dott. Ferrero di acquisire un solido background interdisciplinare che gli consente di applicare e sviluppare le tecniche computazionali per l'analisi integrativa di dati clinici e di stile di vita con dati genomici, epigenomici e trascrittomici nell'ambito di progetti di ricerca di base e applicata.

    In questi contesti, il Dott. Ferrero ha studiato il ruolo di RNA non codificanti, microRNA (miRNA), RNA circolari (circRNA) e RNA lunghi non codificanti (lncRNA) non solo come regolatori trascrizionali ma anche come specifici biomarcatori di patologie o specifici stili di vita che possono essere misurati in i biofluidi. Per queste indagini, nel 2019, il Dott. Ferrero ha vinto una borsa di studio dell'Associazione Italiana per la Ricerca sul Cancro (AIRC) per il progetto "Host-gut microbiome small RNA crosstalk: an innovative source of biomarkers for an accurate colonctal cancer detection".

    Il principale argomento di ricerca del Dr. Ferrero è l'attività molecolare degli RNA extracellulari rilevabili nei biofluidi umani, il loro ruolo nelle malattie complesse (in particolare del tratto gastrointestinale) e le loro modulazioni in relazione all'esposizione individuale a fattori ambientali, tra cui inquinamento, stile di vita e abitudini alimentari. Il ruolo di queste molecole nelle interazioni ospite-microbico è studiato anche mediante l'applicazione di strategie bioinformatiche per l'analisi integrativa dei dati di sequenziamento di nuova generazione.

    English

    Dr. Ferrero is a senior researcher at the Department of Clinical and Biological Sciences. The achievement of the master’s degree in Cellular and Molecular Biology and of the Doctorate in Complex Systems for Life Sciences (University of Turin) allowed Dr. Ferrero to acquire a solid interdisciplinary background allowing him to effectively apply computational techniques for the integrative analysis clinical and lifestyle data with genomic, epigenomic and transcriptomic data in the context of basic and applied research projects.

    In these contests, Dr. Ferrero studied the role of noncoding RNAs, microRNA (miRNAs), circular RNA (circRNAs) and long noncoding RNA (lncRNAs) not only as transcriptional regulators but also as specific biomarkers of pathologies or lifestyle that can be measured in the biofluids. For these investigations, in 2019, Dr. Ferrero was awarded a Fellowship from the Italian Cancer Research Association (AIRC) for the project "Host-gut microbiome small RNA crosstalk: an innovative source of biomarkers for an accurate colorectal cancer detection".

    Dr. Ferrero main research topic is the molecular activity of extracellular RNAs detectable in human biofluids, their role in complex diseases (particularly of the gastrointestinal tract) and their modulations in relationship to individual exposure to environmental factors, including pollution, lifestyle, and dietary habits. The role of these molecules in the host-microbial interactions is also investigated by the application of bioinformatic strategies for the integrative analysis of next-generation sequencing data.

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    Academic bodies

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